AZ 5704 - CAS 1941214-06-7

Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay) . Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM) . Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable.

Others, ATM/ATR

PI3K/Akt/mTOR signaling, Others, DNA Damage/DNA Repair

1941214-06-7

C23H23FN6O2

434.47

N([C@@H](C)C1=NN(C)C=C1)C=2C3=C(C=C(F)C(=C3)C=4C=CC(COC)=NC4)N=CC2C(N)=O

-20°C

Ice Packs

Small Compound