AZ0108 - CAS 1825345-52-5

AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. AZ0108 is more selective in its enzyme inhibition profile and effects on cellular pathways and phenotypes. Specifically, AZ0108 inhibits PARPs 1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. Consistent with this lack of potencytowards tankyrase, AZ0108 is not active in a DLD-1 Wnt luciferase reporter assay.

Others, PARP

Chromatin/Epigenetic, DNA Damage/DNA Repair, Others

1825288

C24H20F4N6O2

500.45

C(C)(F)(F)C=1N2C(CN(C(=O)C3=CC(C(F)(F)C=4C=5C(C(=O)NN4)=CC=CC5)=CC=C3)[C@@H](C)C2)=NN1

-20°C

Ice Packs

Small Compound