AZ31 - CAS 2088113-98-6

AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK family selectivity, and pan-kinase selectivity.AZ31 is a potent in vitro radiosensitizer that can be used for cancer research.

ATM/ATR

PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

2088009

0.981

C24H28N4O3

420.5

N([C@@H](C)C1CCOCC1)C=2C3=C(N=CC2C(N)=O)C=CC(=C3)C=4C=CC(COC)=NC4

-20°C

Ice Packs

Small Compound