AZ5576 racemate - CAS 1333468-05-5

AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.

Bcl-2 Family, Others, c-Myc, CDK

Others, Cell Cycle/Checkpoint, Apoptosis

1333468-05-5

C21H24FN3O3

385.43

O(C)C1=C(C=2C=C(NC(=O)[C@@H]3C[C@H](NC(C)=O)CCC3)N=CC2)C=CC(F)=C1

-20°C

Ice Packs

Small Compound