AZASPIRENE - CAS 461644-34-8

Azaspirene, a novel angiogenesis inhibitor, is based on the 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione framework. Previous studies have shown that Azaspirene effectively inhibits VEGF-induced migration of human umbilical vein endothelial cells (HUVEC), demonstrating a potentially effective dosage. Moreover, azaspirene analogs may exhibit potential antitumor effects against uterine adenocarcinoma, possibly through significant anti-angiogenic activity.

VEGFR, Raf

Tyrosine Kinase/Adaptors, MAPK, Angiogenesis

461602

C21H23NO5

369.41

O[C@@H]1[C@@]2(OC(/C=C/C=C/CC)=C(C)C2=O)C(=O)N[C@]1(CC3=CC=CC=C3)O

-20°C

Ice Packs

Small Compound