AZD 1152 (hydrochloride) - CAS 722543-50-2

AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM) .1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5

Others, Apoptosis, Aurora Kinase

Cell Cycle/Checkpoint, Chromatin/Epigenetic, Others, Apoptosis

722491

C26H33Cl2FN7O6P

660.47

Cl.Cl.CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1)CCOP(O)(O)=O

-20°C

Ice Packs

Small Compound