AZD-1236 - CAS 459814-89-2

AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.

MMP, Others

Others, Proteases/Proteasome

459723

C15H19ClN4O5S

402.85

S(C[C@@]1(C)NC(=O)NC1=O)(=O)(=O)N2CCC(OC3=CC=C(Cl)C=N3)CC2

-20°C

Ice Packs

Small Compound