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Molfinity

AZD0780 - CAS 2455427-91-3

AZD0780 - CAS 2455427-91-3

MF-0063908-01

$59.34 USD
$59.34 USD
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Product Details

  • Bioactivity

    AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM) . It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.

  • Target

    Others

  • Related Pathways

    Others

  • CAS Number

    2455333

  • Purity

    0.9974

  • Molecular Formula

    C20H20F2N6O2

  • Molecular Weight

    414.41

  • SMILES

    FC(F)Oc1cnc(N[C@H]2CC[C@@H](C2)Nc2ccc(cn2)-n2ccccc2=O)nc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound