AZM198 - CAS 1933460-23-1

AZM198 is a selective, orally active, and irreversible inhibitor of MPO with an IC50 of 15.0 nM. It exhibits an IC50 of 19 μM against CYP3A4 and possesses favorable lipophilicity, membrane permeability, metabolic stability, safety, and pharmacokinetic properties. AZM198 shows efficacy in improving vascular function, atherosclerotic plaques, pulmonary hypertension, nephropathy, visceral inflammatory fat deposition, ectopic fat deposition, and liver fibrosis.

Cytochromes P450, Glutathione Peroxidase

Metabolism

1933436

C14H13ClN4OS

320.8

O=C1NC(=S)N(C=2C=CNC12)CC3=CC=C(Cl)C=C3CN

-20°C

Ice Packs

Small Compound