BA6b9 - CAS 609335-29-7

BA6b9 is an allosteric inhibitor targeting the SK4 channel via the CaM-PIP2 binding domain. It interacts with two critical residues, Arg191 and His192, located in the S4-S5 linker to inhibit the SK4 channel, with an IC50 of 8.6 μM (WT SK4) . BA6b9 significantly prolongs the effective refractory period (ERP) of the atria and atrioventricular node in isolated rat hearts, reducing the induction of atrial fibrillation (AF), highlighting its potential for arrhythmia research.

Potassium Channel

Membrane transporter/Ion channel

609335-29-7

C14H19NO2

233.31

O=C1OC=2C=CC=CC2N1CCCCCCC

-20°C

Ice Packs

Small Compound