BACE1-IN-13 - CAS 1397683-26-9

BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM) . It is considered safe for the cardiovascular system and induces a sustained reduction of Aβ42 in both mouse and dog animal models [1].

Beta-Secretase

Neuroscience

1397648

C20H17FN8O2

420.4

C[C@]1(CN2C(C(N)=N1)=CC(C#N)=N2)C3=CC(NC(=O)C=4C=NC(OC)=CN4)=CC=C3F

-20°C

Ice Packs

Small Compound