Balomenib - CAS 2939850-17-4

Balomenib is an inhibitor of the menin-MLL interaction, effectively blocking the men1-MLL4-43 interaction with an IC50 of less than 0.075 μM. It inhibits cell growth in MV4-11 (CC50 < 0.1 μM), MOLM-13 (CC50 0.1~0.5 μM), and HEK293 (CC50 < 2 μM) cells. Balomenib also exhibits antitumor activity.

Epigenetic Reader Domain

Chromatin/Epigenetic

2939829

C33H34F3N7O2

617.664

C(N1CCC2(CN(C2)C=3C4=C(C=CC(CC(F)(F)F)=C4)N=CN3)CC1)C=5C(C)=C6C(=CC5)N(C[C@@H]7CNC(=O)CO7)C(C#N)=C6

-20°C

Ice Packs

Small Compound