Barbadin - CAS 356568-70-2

Barbadin is a novel and specific inhibitor of β-arrestin/β2-adaptin interaction with an IC50 value of 19.1 μM for β-arestin1 and 15.6 μM for β-arestin2. Barbadin potentiates the long term effects of lorcaserin on POMC neurons and weight loss. Barbadin potentiates the long-term effects of lorcaserin on POMC neurons and weight loss, blocks agonist-promoted endocytosis of prototypic β2-adrenergic, V2-vasopressin, and angiotensin-II-1 receptors, and may be useful in the study of obesity.

Arrestin, Apoptosis

GPCR/G Protein, Apoptosis

356496

0.991

C19H15N3OS

333.41

Nn1cnc2scc(-c3ccc(Cc4ccccc4)cc3)c2c1=O

-20°C

Ice Packs

Small Compound