BAY-707 - CAS 2109805-96-9

BAY-707, a highly potent and selective substrate-competitive inhibitor of MTH1 (NUDT1) with an IC50 of 2.3 nM, is well-tolerated in mice and exhibits a favorable pharmacokinetic (PK) profile compared to other MTH1 compounds. However, it demonstrates a clear lack of anticancer efficacy both in vitro and in vivo[1].

DNA/RNA Synthesis, Others

Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2109700

C15H20N4O2

288.34

C(NCC)(=O)C1=CC2=C(C=CN=C2N1)N3[C@@H](C)COCC3

-20°C

Ice Packs

Small Compound