BBI-355 - CAS 2871056-82-3

BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.

Chk

Cell Cycle/Checkpoint

2870971

C19H19N7O2

377.4

O(C1=C(C(OC)=CC=C1)C2=CC(NC=3C=NC(C#N)=CN3)=NN2)[C@@H]4C[C@@H](N)C4

-20°C

Ice Packs

Small Compound