BC-1293 - CAS 1219395-86-4

BC-1293 is an inhibitor of the E3 ligase subunit FBXO24 that acts by disrupting the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) . BC-1293 treatment results in increased levels of DARS2, showing its capacity to stabilize this essential enzyme. Furthermore, BC-1293 elevates levels of cytokines including IL-1β, IL-9, MIP-2, and TNF-α in murine models, thereby demonstrating immunostimulatory activity with potential relevance to immune modulation research.

E1/E2/E3 Enzyme

Ubiquitination

1219395-86-4

0.984

C26H28N4O4S

492.59

O=C(N1CC=C(C=2C=CC=CC2)CC1)C(NS(=O)(=O)C=3C=C(C=CC3C)C4=NOC(=N4)C5CC5)C

-20°C

Ice Packs

Small Compound