BC-1901S - CAS 1358617-36-3

BC-1901S functions as a proteasome-independent activator and stabilizer of NRF2. By binding to DCAF1 (E3 ligase subunit), it disrupts the NRF2/DCAF1 interaction and activates NRF2 through the inhibition of NRF2 ubiquitination, independent of KEAP1. BC-1901S has demonstrated anti-inflammatory effects in a murine model of LPS-induced acute lung injury.

Nrf2, E1/E2/E3 Enzyme

Immunology/Inflammation, Ubiquitination

1358617-36-3

C23H22ClFN4O

424.9

O=C(NC1=CC=C(F)C(Cl)=C1)C2CCN(C3=NC(=NC=C3)C=4C=CC=C(C4)C)CC2

-20°C

Ice Packs

Small Compound