Bcl-2-IN-11 - CAS 2760536-88-5

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor with an IC50 of 0.9 nM and minimal inhibition against Bcl-xl (IC50 > 1000 nM) . It is used in cancer research related to Bcl-2 family protein overexpression, particularly in hematologic malignancies like acute lymphoid leukemia, while minimizing the risk of side effects such as thrombocytopenia [1] by sparing Bcl-xl.

Bcl-2 Family, Others

Others, Apoptosis

2760443

C45H49ClFN7O8S

902.43

O=[N+](C(C=C1S(NC(C(C=CC(N2C[C@H](N(CC2)CC3=C(C4=CC=C(C=C4)Cl)CC(C)(CC3)C)C)=C5)=C5OC6=CN=C(NC=C7)C7=C6)=O)(=O)=O)=C(C(F)=C1)NC[C@H]8COCCO8)[O-]

-20°C

Ice Packs

Small Compound