BE-16627B - CAS 137530-61-1

BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.

Others

Others

137468

C16H29N3O7

375.42

C(C(N[C@H](C(N[C@@H]([C@@H](C)C)C(O)=O)=O)CO)=O)(CC(NO)=O)CC(C)C

-20°C

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Small Compound