Beclin1-ATG14L interaction inhibitor 1 - CAS 1243063-73-1

Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L. It impedes the formation of complex I in the lipid kinase VPS34, thus inhibiting autophagy, while leaving complex II intact, which relies on the Beclin 1-UVRAG interaction for its integrity and is essential for vesicle transport [1].

Autophagy

Autophagy

1242989

C23H24N4O5S

468.53

O=C1N(C2=CC(=CC=C2OC1)S(=O)(=O)NC3=CC=CC(=C3C)C)CC4=NOC(=N4)C5CCC5

-20°C

Ice Packs

Small Compound