BET/Aurora kinase-IN-1 - CAS 2674064-32-3

BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.

Aurora Kinase

Chromatin/Epigenetic, Cell Cycle/Checkpoint

2674029

C25H30FN7O

463.55

CC1=C(C(=NN1C)C2CC2)C3=NC(NC=4C=C5C(=CC4)N(C)C(=O)[C@@H](C)N5C(C)C)=NC=C3F

-20°C

Ice Packs

Small Compound