Bexagliflozin diproline - CAS 1118567-48-8

Bexagliflozin (also known as EGT1442) is a potent and selective SGLT2 inhibitor that effectively reduces blood glucose and HbA (1c) levels in db/db mice while increasing the survival time of stroke-prone rats. The IC (50) values of EGT1442 for human SGLT1 and SGLT2 are 5.6 μM and 2 nM, respectively. In studies involving normal rats and dogs, EGT1442 induces saturated urinary glucose excretion with ED (50) values of 0.38 mg/kg and 0.09 mg/kg, respectively. Additionally, EGT1442 exhibits favorable properties in both in vivo and in vitro studies, indicating its potential positive impact on the management of type 2 diabetes.

1118511

C34H47ClN2O11

695.2

OC([C@@H]1CCCN1)=O.O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)C3=CC(CC4=CC=C(C=C4)OCCOC5CC5)=C(C=C3)Cl.OC([C@@H]6CCCN6)=O

-20°C

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Small Compound