BF-170 - CAS 22191-97-5

BF-170 is a selective tau fiber-binding agent with an EC50 of 221 nM. It demonstrates excellent blood-brain barrier penetration, reaching a concentration of 9.1% ID/g in brain tissue 2 minutes after intravenous injection in mice (with a clearance rate of 0.25% ID/g at 30 minutes) . BF-170 can serve as a probe for imaging tau protein pathology in Alzheimer's disease (AD) . It plays a significant role in early-stage Alzheimer's disease studies and holds promise for imaging research in tau-related neurodegenerative diseases.

Microtubule Associated

Cytoskeletal Signaling

22089

C15H12N2

220.269

N=1C=2C=CC=CC2C=CC1C=3C=CC(N)=CC3

-20°C

Ice Packs

Small Compound