BFC1103 - CAS 701231-39-2

BFC1103 is a small molecule compound that primarily interacts with a specific domain of Bcl-2, particularly its loop domain. This interaction causes a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homologous 3) domain and switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of either Bax or Bak, both of which are crucial proteins in the mitochondrial-mediated intrinsic apoptosis pathway. In mouse models, BFC1103 effectively inhibited lung metastasis of triple-negative breast cancer. BFC1103 can be used to study the role of Bcl-2 family proteins in cancer development and their impact on cancer cell survival and proliferation.

Bcl-2 Family

Apoptosis

701231-39-2

C20H26N2O3S

374.5

O=C(NC1=CC=C(C=C1)CCCC)CN(CC=2C=CC=CC2)S(=O)(=O)C

-20°C

Ice Packs

Small Compound