BI-0115 - CAS 4929-23-1

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.

Lipoxygenase

Metabolism

4905

0.9969

C15H14ClN3O

287.74

CCCN1c2cccnc2Nc2cc(Cl)ccc2C1=O

-20°C

Ice Packs

Small Compound