BI-0252 - CAS 1818291-27-8

BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM) . BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.

E1/E2/E3 Enzyme, MDM-2/p53, Others

Ubiquitination, Others, Apoptosis

1818256

C30H26Cl2FN3O3

566.45

C(N1[C@@]2([C@H]([C@]3([C@@]1(C[C@@H](N3)C4=CC=C(C(O)=O)C=C4)[H])[H])C5=C(F)C(Cl)=CC=C5)C=6C(NC2=O)=CC(Cl)=CC6)C7CC7

-20°C

Ice Packs

Small Compound