BI-1622 - CAS 2681392-19-6

BI-1622 is a highly selective, orally active HER2 (ERBB2) inhibitor (IC50: 7 nM) . BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited high in vivo antitumor effects with good drug metabolism and pharmacokinetic properties.

Others, BTK, PI4K, JAK, EGFR, Raf, CDK, Tyrosine Kinases

Chromatin/Epigenetic, JAK/STAT signaling, MAPK, Stem Cells, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Others, Angiogenesis

2681392-19-6

C26H24N10O2

508.53

N(C=1C2=C(C=NC(=N2)N3CCN(C(C=C)=O)CC3)N=CN1)C4=CC(C)=C(OC5=CC=6N(C=C5)N=CN6)C=C4

-20°C

Ice Packs

Small Compound