BI-3802 - CAS 2166387-65-9

BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependent on the E3 ligase SIAH1, demonstrating notable antitumor activity[1][2].

Bcl-2 Family, Molecular Glues, Bcl-6

PROTAC, Apoptosis, Immunology/Inflammation

2166313

0.9948

C24H29ClN6O3

484.98

CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3C[C@@H](C)C[C@@H](C)C3)ccc2n(C)c1=O

-20°C

Ice Packs

PROTAC