BI-4020 - CAS 2664214-60-0

BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM) . BI-4020 also shows high kinome selectivity and good DMPK properties.

EGFR

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

2664154

>99.99%

C30H38N8O2

542.68

C[C@@H]1CCCOc2c(cnn2C)-c2cc(cc(C)n2)C(=O)\N=C2/Nc3ccc(CN4CCN(C)CC4)cc3N2C1

-20°C

Ice Packs

Small Compound