Bicuculline - CAS 485-49-4

Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM) . It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP) . Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.

GABA Receptor

Neuroscience, Membrane transporter/Ion channel

432

0.9999

C20H17NO6

367.35

[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12

-20°C

Ice Packs

Natural Product