Binucleine 2 - CAS 220088-42-6

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. At 40 μM, Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells and prevents the assembly of a contractile ring during cell division in Drosophila S2 cells, but it does not affect ring ingression, indicating that Aurora B kinase activity is not required for that process.

Others, Aurora Kinase

Cell Cycle/Checkpoint, Others, Chromatin/Epigenetic

220088-42-6

C13H11ClFN5

291.71

N(=CN(C)C)C=1N(N=CC1C#N)C2=CC(Cl)=C(F)C=C2

-20°C

Ice Packs

Small Compound