Bis-sulfone-PEG4-NHS ester - CAS 2055047-19-1

Bis-sulfone-PEG4-NHS ester is a bifunctional alkylating labeling reagent that selectively removes cysteine sulfur atoms from native disulfide bonds. These reagents perform bis-alkylation to attach both thiols from two cysteine residues, originating from reduced native disulfide bonds (such as interchain disulfide bonds in antibodies) . The reaction results in a covalent bond through a three-carbon bridge, maintaining the protein's structural integrity. The hydrophilic PEG spacer enhances its solubility in aqueous media.

2055047-19-1

C40H48N2O14S2

844.944

O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C(=O)C(CS(=O)(=O)C3=CC=C(C=C3)C)CS(=O)(=O)C4=CC=C(C=C4)C

-20°C

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