Bis-sulfone-PEG8-NHS ester - CAS 2363757-66-6

Bis-sulfone-PEG8-NHS ester is a bis-alkylating labeling agent that selectively removes cysteine sulfur atoms from native disulfide bonds. These agents achieve bis-alkylation by covalently bridging the two thiols from cysteine residues derived from reduced native disulfide bonds, such as interchain disulfide bonds in antibodies, through a three-carbon bridge while maintaining the integrity of the protein structure. The hydrophilic PEG spacer enhances solubility in aqueous media.

2363757-66-6

C48H64N2O18S2

1021.15

O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C(=O)C(CS(=O)(=O)C3=CC=C(C=C3)C)CS(=O)(=O)C4=CC=C(C=C4)C

-20°C

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