Bischloroanthrabenzoxocinone - CAS 866022-28-8

Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 μg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 μg/ml. BABX also displays binding to liver X receptors (LXRs), inhibiting agonist binding in an LXRα-scintillation proximity assay (IC50 = 10 μM) .

Others, Antibacterial

Microbiology/Virology, Others

865986

C28H24Cl2O7

543.39

[H][C@@]12O[C@@](C)(Cc3cc4c(C(=O)c5c(O)c(Cl)c(O)c(Cl)c5C4(C)C)c(O)c13)Oc1cc(OC)cc(C)c21 |TLB:25:27:37.29.28:2,30:29:2:27.5.6,35:37:2:27.5.6|

-20°C

Ice Packs

Small Compound