Bisdemethoxycurcumin - CAS 24939-16-0

Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

DNA/RNA Synthesis, P-gp, Ferroptosis, Epigenetic Reader Domain, Wnt/beta-catenin

Cell Cycle/Checkpoint, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair, Neuroscience, Cytoskeletal Signaling, Membrane transporter/Ion channel, Stem Cells

24923

0.9975

C19H16O4

308.33

Oc1ccc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)cc1

-20°C

Ice Packs

Natural Product