BJE6-106 - CAS 1564249-38-2

BJE6-106 (B106) is a selective PKCδ inhibitor (IC50 = 0.05 μM) with 1000-fold higher selectivity for PKCδ than PKCα (IC50 = 50 μM) . BJE6-106 induces caspase-dependent apoptosis, activates the JNK pathway and H2AX, and can be used to study NRAS-mutated melanoma.

PKC, Caspase, Apoptosis, JNK

Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis, Cytoskeletal Signaling, MAPK

1564209

C26H23NO2

381.47

O=CC1=CC(=CC=2C=CC(OC12)(C)C)CCN3C=4C=CC=CC4C=5C=CC=CC53

-20°C

Ice Packs

Small Compound