BLU-945 - CAS 2660250-10-0

BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs) . BLU-945 inhibits EGFR phosphorylation in EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S mutant cell lines. BLU-945 can be used in lung cancer research, including non-small cell lung cancer (NSCLC) .

EGFR

JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis

2660240

0.9916

C28H37FN6O3S

556.7

CO[C@@H]1CCN(C[C@@H]1F)c1nccc(Nc2cc3c(ccc(N4C[C@H](CS(C)(=O)=O)[C@H]4C)c3cn2)C(C)C)n1

-20°C

Ice Packs

Small Compound