BLX3887 - CAS 934758-70-0

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay) .1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM) . BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.

Others, Lipoxygenase

Others, Metabolism

934688

C10H5Cl3FN3O

308.52

Fc1ccc(NC(=O)c2n[nH]c(Cl)c2Cl)c(Cl)c1

-20°C

Ice Packs

Small Compound