BM-1244 - CAS 1619923-32-8

BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].

Others, Apoptosis, PARP, Bcl-2 Family, Caspase

Others, Proteases/Proteasome, DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic

1619883

C54H59ClF4N6O8S4

1159.78

CC(C)n1c(C)c(c(c1-c1ccc(Cl)cc1)-c1cc(F)cc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(CC3)C(O)=O)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)cc1)S(C)(=O)=O

-20°C

Ice Packs

Small Compound