BML-278 - CAS 120533-76-8

BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.

Histone Methyltransferase, Sirtuin

DNA Damage/DNA Repair, Chromatin/Epigenetic

120449

>99.99%

C24H25NO4

391.46

CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC

-20°C

Ice Packs

Small Compound