BMS-1001 hydrochloride - CAS 2113650-04-5

BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is capable of alleviating the PD-1/PD-L1 immune checkpoint-mediated exhaustion of Jurkat T-lymphocytes.

PD-1/PD-L1

Apoptosis, Cell Cycle/Checkpoint, Immunology/Inflammation

2113650-04-5

0.9957

C35H35ClN2O7

631.11

Cl.Cc1cc(CN[C@H](CO)C(O)=O)c(OCc2cccc(c2)C#N)cc1OCc1cccc(c1C)-c1ccc2OCCOc2c1

-20°C

Ice Packs

Small Compound