BMS-1166-N-piperidine-CO-N-piperazine - CAS 2447066-14-8

BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound containing a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It is used in synthesizing [PROTAC PD-1/PD-L1 degrader-1], which effectively inhibits the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM.

Target Protein Ligand-Linker Conjugate, Others

Others, PROTAC

2447044

C41H43ClN4O5

707.27

Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1

-20°C

Ice Packs

PROTAC