BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride - CAS 2691796-83-3

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1) /programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1/PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1/PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.

PD-1/PD-L1, Target Protein Ligand-Linker Conjugate

Cell Cycle/Checkpoint, Immunology/Inflammation, PROTAC, Apoptosis

2691710

0.9894

C41H45Cl3N4O5

780.18

Cl.Cl.Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)N3CCNCC3)cc2Cl)cccc1-c1ccc2OCCOc2c1

-20°C

Ice Packs

PROTAC