BMS-509744 - CAS 439575-02-7

BMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.

Others, IL Receptor, HIV Protease, Immunology/Inflammation related, Tyrosine Kinases

Tyrosine Kinase/Adaptors, Microbiology/Virology, Proteases/Proteasome, Others, Immunology/Inflammation

439575-02-7

0.997

C32H41N5O4S2

623.83

O=C(NC1=NC=C(S1)SC2=CC(=C(OC)C=C2C)C(=O)N3CCN(C(=O)C)CC3)C4=CC=C(C=C4)CNC(C)C(C)(C)C

-20°C

Ice Packs

Small Compound