BMS-818251 - CAS 2974489-09-1

BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the conserved β20-β21 hairpin.

HIV Protease

Microbiology/Virology, Proteases/Proteasome

2974489-09-1

C29H26N6O5S

570.619

N#CC(C=1C=CC=CC1)=C2CCN(C(=O)C(=O)C3=CNC4=C(N=CC(OC)=C34)C=5N=C(SC5)C(=O)NCCO)CC2

-20°C

Ice Packs

Small Compound