BMS-986470 - CAS 3036554-12-5

BMS-986470 is a CRBN E3 ubiquitin ligase modulator (CELMoD) that activates fetal hemoglobin (HbF) . It is an orally available molecular glue degradator targeting ZBTB7A and WIZ protein degradation, thereby inducing gamma globin synthesis and activating HbF. It is applicable for studying sickle cell disease (SCD) .

Molecular Glues

PROTAC

3036537

C29H25N5O5

523.54

N(C1=C2C(C(=O)N(C2=O)[C@@H]3C(=O)NC(=O)CC3)=CC=C1)C4=C(C=C5C(=C4)N(C)C(=O)CC5)C=6C=C(C)N=CC6

-20°C

Ice Packs

PROTAC