BMY-42393 - CAS 136451-58-6

BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM) . BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM) . Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. BMY 42393 competed for radiolabeled iloprost and PGE1 binding to platelet membranes (IC50; 170 nM and 130 nM, respectively) .

Prostaglandin Receptor, Others

Others, Immunology/Inflammation, GPCR/G Protein

136387

C25H21NO4

399.44

C(CC1=CC(OCC(O)=O)=CC=C1)C2=NC(=C(O2)C3=CC=CC=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound