BMY 7378 free base - CAS 21102-94-3

BMY 7378 (free base) is a selective antagonist for the α1D adrenergic receptor (α1D-AR) . It exhibits a membrane-binding affinity for cloned rat α1D-AR (Ki=2 nM) that is over 100 times stronger than its affinity for cloned rat α1A-AR (Ki=800 nM) or hamster α1B-AR (Ki=600 nM) . Additionally, BMY 7378 (free base) acts as a partial agonist at the 5-HT1A receptor.

Adrenergic Receptor, 5-HT Receptor

Neuroscience, GPCR/G Protein

21005

C22H31N3O3

385.5

O=C1N(C(=O)CC2(C1)CCCC2)CCN3CCN(C=4C=CC=CC4OC)CC3

-20°C

Ice Packs

Small Compound