BOLD-100 free base - CAS 783324-98-1

BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.

HSP, Autophagy, Others

Cytoskeletal Signaling, Others, Metabolism, Autophagy

783225

C14H12Cl4N4Ru

479.15

[Cl-][Ru+4]([Cl-])([Cl-])([Cl-])([N]1=CC=2C=CC=CC2N1)[N]3=CC=4C=CC=CC4N3

-20°C

Ice Packs

Small Compound