BPIQ-II (hydrochloride) - CAS 171179-37-6

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM) . It is selective for EGFR over other tyrosine and serine/threonine kinases, and cellular studies show that BPIQ-II can selectively inhibit EGF-stimulated signal transmission by competitively binding at the ATP site of EGFR.

Others, EGFR

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Others

171136

C15H11BrClN5

376.64

Cl.BrC1=CC=CC(=C1)NC2=NC=NC3=CC=4N=CNC4C=C32

-20°C

Ice Packs

Small Compound